Nina A. Ran, MD, MSEmily E. Granger, MDDavid G. Brodland, MD; et al
Key Points
Question In cutaneous squamous cell carcinoma, how is the number of risk factors associated with the risk of recurrence, metastasis, and disease related death?
Findings In this cohort study of 16 844 cases of cutaneous squamous cell carcinoma, tumors were stratified by the number of the following risk factors (0, 1, 2, 3, or 4): a diameter of 2 cm or larger, poorly differentiated histology, tumor extension beyond subcutaneous fat, and large caliber nerve invasion. Every incremental increase in the number of risk factors was associated with a greater risk of local recurrence, metastasis, and disease-related death.
Meaning The study results suggest that among individuals with cutaneous squamous cell carcinomas, the number of risk factors is an important indicator of risk.
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