Abstract
Importance: High-stage cutaneous squamous cell carcinoma (cSCC) has an increased risk of recurrence, metastasis, and mortality. Studies investigating the outcomes of high-stage cSCC among patients treated with Mohs surgery compared with those treated with wide local excision (WLE) are limited.
Objective: To assess the outcomes of primary high-stage cSCC among patients treated with Mohs surgery compared with those treated with WLE.
Design, setting, and participants: This retrospective cohort study using propensity score weighting was conducted in a tertiary academic medical center in Boston, Massachusetts. Patients were included if they had primary high-stage cSCC and had been treated with either Mohs surgery or WLE between January 1, 2000, and December 31, 2019. Data analysis was performed between November 3 and 6, 2023.
Exposures: Primary surgical treatment with Mohs surgery or WLE.
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